• DILIsym web promo

    DSSI Evaluates Prospective NAFLD Treatments with Pfizer, Inc.

    Collaboration uses new software, NAFLDsym™ 



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    DSSI and Otsuka Joint Publication


    DILIsym used to identify mechanisms of Tolvaptan hepatotoxicity



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    DILIsym at the PSTC BSEP Webinar Series

    Presentations by Dr. Paul Watkins and Dr. Brett Howell at the PSTC BSEP Webinar Series


DILIsym®: An In Silico Model of Drug-Induced Liver Injury 

DILIsym® is a “middle-out”, multi scale computational model of drug-induced liver injury (DILI). The software is designed to be used during drug development to provide an enhanced understanding of the DILI hazard posed by individual molecules and to provide deeper insight into the mechanisms responsible for observed DILI responses at various stages of the development process.

Dr. Paul WatkinsThe DILI-sim Initiative is a consortium of life science companies led by DILIsym Services, Inc. and charged with developing the DILIsym® software. The goals of the Initiative are to improve patient safety, reduce the need for animal testing, and reduce the costs and time necessary to develop new drugs.

The Initiative is led by Dr. Paul B. Watkins, Director of the University of North Carolina Institute for Drug Safety Sciences, located in the heart of Research Triangle Park, North Carolina. 

Companies Supporting DILIsym® Software Development

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