• DILIsym7A Logo

    DILIsym Services, Inc., a Simulations Plus Company, Releases DILIsym® Version 7A 

    Significant update of liver safety program includes performance and capability enhancement   




  • Highlighted Liver-560x310

    Simulations Plus Closes Acquisition of DILIsym Services, Inc.  

    DILIsym Services, Inc. has become a wholly owned subsidiary of Simulations Plus 


  • DILIsym_Process_DSS_promo

    BioWorld Article 


    DILIsym and DILI-sim Initiative Highlighted at Digestive Disease Week (DDW) 2017



DILIsym®: An In Silico Model of Drug-Induced Liver Injury 

DILIsym® is a “middle-out”, multi scale computational model of drug-induced liver injury (DILI). The software is designed to be used during drug development to provide an enhanced understanding of the DILI hazard posed by individual molecules and to provide deeper insight into the mechanisms responsible for observed DILI responses at various stages of the development process.

Dr. Paul WatkinsThe DILI-sim Initiative is a consortium of life science companies led by DILIsym Services, Inc. and charged with developing the DILIsym® software. The goals of the Initiative are to improve patient safety, reduce the need for animal testing, and reduce the costs and time necessary to develop new drugs.

The Initiative is led by Dr. Paul B. Watkins, Director of the University of North Carolina Institute for Drug Safety Sciences, located in the heart of Research Triangle Park, North Carolina. 

Companies Supporting DILIsym® Software Development


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